Spotlight Research 5 - Uncertainty in Illness and Psychological Adjustment in Patients with Systemic Lupus Erythematosus

Systemic Lupus Erythematosus (SLE) is a chronic condition marked by its unpredictable nature, which often heightens the risk of experiencing illness-related uncertainty. Research indicates that uncertainty in illness can negatively impact psychological adjustment across various chronic conditions. This cross-sectional descriptive study examined the relationship between illness-related uncertainty and psychological adjustment in adults living with SLE.A total of 78 patients diagnosed with SLE participated in an online survey evaluating illness-related uncertainty, psychological adjustment, quality of life, and social determinants of health. Of the 78 participants, 91% identified as female (N=71), 51% identified as Black (N=40), 96% of participants were insured with the majority (N=39) reportedly insured via public insurance (Medicaid/Medicare). Participants age ranged from 24 to 79 years (51.5±14.4) and duration of diagnosis ranged from 1 to 63 years (20.5±12.8). Uncertainty in illness was found to be positively correlated with depression (r = .50, p < .001), anxiety (r = .52, p < .001) and negatively correlated with non-health related quality of life (NHRQL) (r = -.30, p = .008). The findings indicate that illness-related uncertainty is associated with increased symptoms of anxiety and depression, as well as a negative impact on non-health-related quality of life (NHHRQL) in individuals with SLE. These results align with previous research on SLE and other chronic illnesses. The implications highlight the potential value of interventions aimed at reducing illness-related uncertainty to alleviate psychological distress in individuals with SLE. This study aligns with the conference theme by highlighting how illness-related uncertainty in chronic conditions like SLE impacts psychological well-being, underscoring the need for inclusive, evidence-based interventions that enhance the reach and efficacy of cognitive and behavioral therapies for diverse patient populations. This presentation will explore the impact of illness-related uncertainty on psychological adjustment and quality of life in adults with SLE, highlighting the potential implications for improving patient well-being and informing future interventions.